Giant lymphoproliferative disorder, also known as vascular follicular lymphoid hyperplasia, is a relatively rare lymphoproliferative disorder. It is a relatively rare lymphoproliferative disorder. The following is an explanation of the disease concept, clinical staging and specific treatments. 1. Giant lymphoid hyperplasia is characterized by markedly different degrees of vascular, lymphoid follicular, and plasma cell hyperplasia, and significant enlargement of deep and superficial lymph nodes. Giant lymph node hyperplasia is a complex clinical disease with clinical manifestations similar to lymphoma, but its histologic features are different from those of lymphoma. 2. The common clinical manifestations of Macrolymphatic hyperplasia are classified as monocentric and multicentric. The unicentric type is characterized by the development of a single lymph node, while the multicentric type is generally characterized by the enlargement of multiple lymph nodes throughout the body. Common histologic classifications include hyaline vascular, plasma cell, and mixed types. The disease is mostly found in the intrathoracic, especially mediastinal region, and the unicentric type is predominant. 3. Unicentric type can be treated by surgical resection; the treatment of multicentric type is more complicated, and surgical treatment is also considered, but the prognosis is poorer. Specific diagnosis and treatment should be carried out under the guidance of physicians.