Accompanied by sepsis, surgery requires local anesthesia has certain risks, in addition to the risk of local anesthesia itself, but also due to sepsis aggravated circulatory failure. 1. The risk of local anesthesia itself: including local anesthetic poisoning caused by accidental entry into blood vessels within a short period of time, a small number of patients can be allergic to anesthetics, nerve block anesthesia can cause nerve damage, puncture may lead to hematoma or infection and other risks. 2. Aggravate circulatory failure: when the septicemia patients with unstable hemodynamics undergo subarachnoid block anesthesia, due to the blockade of sympathetic nerves, to a certain extent, affecting hemodynamics, it will lead to aggravation of circulatory failure in septicemia patients. When performing local anesthesia in patients with sepsis, a detailed consultation with a medical professional should be made to carefully assess the risks and weigh the pros and cons.