Elevated leukocytes with neutrophils are usually indicative of a bacterial infection and require the use of anti-infective medication as appropriate. There are many reasons for elevated leukocytes with neutrophils, such as hematologic disorders, which usually require bone aspiration. Some patients who use hormones may also show this, and it also depends on the patient’s specific condition. There are also some non-infectious diseases, such as adult Still’s disease, which can present with elevated leukocytes and neutrophils, and generally anti-infective treatment is ineffective and requires treatment with hormones. Therefore, the cause of leukocyte with neutrophil elevation should be analyzed mainly according to the patient’s specific condition.