Platelets 480 x 10⁹/L generally require treatment, and the cause needs to be identified and treated. The normal range for platelets is (100-300) × 10⁹/L. When platelets are >450 × 10⁹/L, a pathologic increase in platelets is often considered. This condition is common in myeloproliferative disorders such as primary thrombocythemia and true erythrocytosis, as well as in diseases such as chronic granulocytic leukemia. It can also occur in conditions such as acute blood loss, infection, splenectomy, and inflammation. In this case, it is necessary to treat the cause of the disease, such as primary thrombocythemia can be treated with hydroxyurea, aspirin and other drugs. When the test sheet suggests that the platelets are 480×10⁹/L, it is recommended to ask the doctor or go to the hematology specialist in time, usually need to complete a series of tests such as bone marrow aspiration, biopsy, ultrasound, CT, blood sampling and other tests to clarify the cause of the disease, and then treated under the guidance of the physician to treat the cause of the disease.