Pressure in the middle of sternum may be related to heart disease, esophageal cancer, thymoma, neurosis and other reasons. 1. Cardiac diseases: such as heart failure, due to decreased ejection capacity of heart and lack of oxygen in tissues, pressure sensation in the middle of sternum can be produced; such as angina pectoris and myocardial infarction, in addition to pressure sensation in the middle of sternum, there are also pain in anterior region of the heart, dyspnea, sweating and other manifestations. 2. Esophageal cancer: if the tumor of esophageal cancer is large and presses the esophagus and trachea, dyspnea and pressure in the middle of sternum can occur. 3. Thymoma: if thymoma compresses the trachea, breathing will be obstructed, resulting in a sense of pressure in the middle of sternum. 4. Neurosis: the patient himself has no organic disease, due to mental tension, stress and other reasons consciously have a sense of pressure in the middle of the sternum, the symptoms may disappear after getting enough rest, appeasement. It is recommended that the person who has a feeling of pressure in the middle of the sternum should go to the hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor, so as not to delay the disease and bring adverse effects to the body.