A misdiagnosis of hyperemesis gravidarum is possible without a pathologic biopsy. Staphylococcus is a gynecological disease caused by abnormal proliferation of placental villous trophoblast cells, which will lead to the appearance of abnormal blisters resembling grapes on the placenta after pregnancy. Although the improvement of modern medical technology has made the diagnosis and treatment of hyperemesis gravidarum less difficult, it cannot be ruled out that some patients may be misdiagnosed in the early stage of the disease, especially in the case of partial hyperemesis gravidarum, although the possibility of misdiagnosis is low. Generally speaking, ordinary tests cannot fully confirm the diagnosis of hyperemesis gravidarum, and patients need to undergo a comprehensive analysis through pathological biopsy and other tests before a clear diagnosis of hyperemesis gravidarum can be made, and then relevant treatments can be implemented. Once a woman is diagnosed with hyperemesis gravidarum, she should receive scientific treatment as soon as possible.