Bilateral lower extremity edema in patients with cerebral infarction may be related to medication. In addition to the drug relationship, double lower extremity edema may also be related to reduced activity, abnormal renal function, autonomic nerve function damage, and so on. It is recommended that the patient go to the hospital in time to clarify the cause of the disease. Double lower extremity edema in patients with cerebral infarction may be related to drugs. If the patient with cerebral infarction is accompanied by hypertension and is taking drugs to control blood pressure, certain drugs to control blood pressure, such as dihydropyridine calcium channel blockers, can trigger the adverse reaction of lower limb edema. In addition to the adverse effects of drugs, bilateral lower extremity edema may be caused by the patient’s reduced activity, bilateral lower extremity deep vein thrombosis or sodium retention. It is also possible that the patient’s renal function is abnormal, or cerebral infarction leads to autonomic function damage caused by double lower extremity edema. It is recommended that the patient go to the hospital in time, complete the relevant examinations, clarify the cause of the disease, and treat the cause of the disease.