Vulvar leukoplakia cannot usually be completely eradicated. Vulvar leukoplakia is a lesion in which the skin and mucosal tissues of the vulva of women undergo pigmentary changes and degeneration. The exact cause of the disease is not clear, and may be related to autoimmunity, changes in estrogen levels, heredity and local chronic irritation. Patients usually manifested as vulvar skin and mucous membrane hypopigmentation appearing large white spots, labia atrophy, vulvar itching unbearable. Early stage of vulvar leukoplakia can be treated with medication, such as clobetasol ointment, tacrolimus ointment, vinyl estradiol ointment, etc. Physical therapy, such as Bohm light, liquid nitrogen freezing, etc., can also be used. For those whose skin lesions are too large or have a tendency of malignant transformation, surgical excision is required. After standardized treatment, the patient’s symptoms can be relieved, but cannot be cured. It is recommended that patients seek timely medical treatment under the guidance of doctors. Patients also need appropriate daily exercise, exercise, keep the vulva clean, reduce the secretion stimulation, to prevent the symptoms from worsening.