Esophagitis is an inflammation of the mucous membrane of the esophagus due to abnormal irritation, edema and congestion. These irritations include stomach acid, bile from duodenal regurgitation, strong alcohol, chili peppers, too hot vegetable soup, too hot tea, etc. Viral infections can also cause esophagitis when the patient’s resistance is reduced. Barret’s esophagus is a pathological phenomenon in which the compound squamous epithelium of the lower esophagus is replaced by a single layer of columnar epithelium. The various forms of mucosal erythema seen on gastroscopy in the lower esophagus are often Barrett’s esophagus. When patients develop esophagitis, ulcers, or cancer, they will have corresponding reflux symptoms, and some of the Barret’s epithelium is prone to cancer. Therefore, esophagitis and Barrett’s esophagus are often causal factors. The main treatment is anti-acid and anti-reflux, proton pump inhibitor such as rabeprazole 20mg/d or H2 receptor antagonist such as cimetidine 0.4 2/d, 0.8 1/night and gastrointestinal motility drug morpholine 10mg 3/d or mosapride 5-10mg 3/d. After correction of reflux, some Barret epithelium can be reversed to squamous epithelium. Surgical treatment can be considered when internal anti-reflux is ineffective. Regular endoscopic follow-up should be performed during the course of internal treatment to observe the effect after treatment, which can reduce the risk of carcinoma once reversed. For some patients with ineffective antacid treatment, gastric mucosal repair agent plus Chinese medicine can be tried.