Drinking alcohol and taking cold medicine can easily produce disulfiram-like reactions and also lead to liver damage. Because alcohol and drugs are prone to allergic reactions, serious cases such as anaphylaxis and clinical death can occur, especially when the cold is secondary to bacterial infection, the application of antibiotics will further increase the chances of allergy, which can also increase the burden on the liver and lead to an increased likelihood of liver damage. So it is recommended to take cold medicine after alcohol metabolism, you can choose to take cold medicine after 24 hours of drinking alcohol. Alcohol consumption should be strictly prohibited during the period of medication and treatment, because it can not only lead to liver damage, but also reduce the immunity of the human organism, and people are weak when they have a cold.