The etiology of high total phosphorus is complex, which can be seen in renal insufficiency, hypoparathyroidism, use of phosphorus-containing drugs, etc. The treatment is mainly medication, such as calcium carbonate, sevelamer, etc., and dialysis can also be chosen. In acute and chronic renal insufficiency, glomerular filtration rate decreases, renal excretion of phosphorus decreases, and blood phosphorus rises, which can induce increased release of bone salts and further lead to high total phosphorus. Treatment should actively treat the primary disease, such as hypertension caused by the use of valsartan, enalapril, etc., and the use of phosphorus-binding agents such as calcium carbonate, sevelamer, etc.. Hypoparathyroidism can also cause high total phosphorus, mainly due to the increased absorption of phosphorus by renal tubules, the treatment is mainly drug therapy, supplemental calcium and active vitamin D such as osteotriol. High total phosphorus can also be seen in the use of phosphorus-containing drugs, the treatment can reduce or replace other drugs, the use of calcium carbonate, svelamer, etc. to reduce phosphorus, and dialysis treatment can be used if necessary. High total phosphorus should actively seek medical attention, standardize the use of drugs under the guidance of the doctor, and monitor electrolyte changes during the use of drugs.