The pharmacological effect of Sacubitril is to inhibit the action of enkephalinase, reduce the degradation of cerebral natriuretic peptide in the body, increase the concentration of natriuretic peptide in the brain, and exert the effect of anti-heart failure. Sacubitril is clinically used for the treatment of heart failure, is an endogenous hormone, with vasodilatation, diuresis, inhibition of the body’s renin-aldosterone, angiotensin system, reduce the load on the heart, as well as inhibit ventricular remodeling, the main effect is anti-heart failure. Sacubitril works by increasing the concentration of brain natriuretic peptide to exert anti-heart failure effects, but when treating heart failure, it also needs to be used with other antidiuretic hormones to work better. Adverse effects of Sacubitril include dizziness, nausea, vomiting, etc. It is contraindicated in patients who are allergic to the components of the drug. When choosing Sacubitril for the treatment of heart failure in the clinic, the drug should be used under the guidance of a physician.