Photodynamic therapy for genital erythema is not always reliable. Genital erythema can be caused by a variety of conditions such as condyloma acuminatum or glans circumcision. Patients can properly choose photodynamic therapy to stabilize the skin and also control the pathogens to a certain extent, so the treatment of genital erythema is reliable. Patients who choose photodynamic therapy for genital erythema should also pay attention to following the doctor’s instructions for medication, and pay attention to do a good job of protecting the surrounding normal tissues to avoid damage to the surrounding skin. Erythema of the genitals can also be seen in syphilis, through photodynamic therapy does not relieve the symptoms, which is unreliable. Photodynamic therapy genital erythema for a long time did not return to normal, the patient should stop using the method of treatment in time, and go to the hospital to consult the doctor, under the guidance of the doctor to choose the appropriate method of treatment.