PICC refers to central venous catheterization via peripheral vein puncture, and has been widely used in clinical practice for patients who require long-term infusion of fluids, such as those requiring long-term nutritional support. In addition, PICC is also a type of intravenous indwelling catheter, which belongs to the indwelling catheter of central vein, and usually can be used for blood transfusion.PICC is to use the catheter to puncture the vein from the peripheral arm, and the catheter reaches to the large vein close to the heart directly, the needle can be inserted directly in the heparin cap during infusion, and the catheter needs to be sealed with the heparin saline or the pulsed positive-pressure sealing of special sealing liquid after infusion.PICC belongs to the type of channel for infusion PICC can be used for blood transfusion therapy, and it can also reduce the pain caused by repeated puncture to the patient and the fear of injections, thus reducing the patient’s psychological and physiological pain and discomfort. It should be noted that after blood transfusion through PICC, saline needs to be given immediately to flush the lumen with pulsatile push to prevent blood from staying in the lumen to form thrombus. In addition, chest radiographs are needed to localize the successful placement of the tube before transfusion, and regular tube care is also needed to prevent tube blockage.