Platelets suddenly low to 14×10⁹/L is considered to be related to aplastic anemia, hypersplenism, primary immune thrombocytopenia, leukemia, etc., which needs to be treated with medication and surgery in conjunction with the condition. Normal human platelet range value is (100~300)×10⁹/L, while platelet 14×10⁹/L belongs to the severe reduction of platelet count. 1. Aplastic anemia: first of all, daily attention should be paid to avoiding infection, preventing bleeding, etc., giving anti-lymphocyte/thymocyte globulin, cyclosporine, androgens such as stanozolol, etc., hematopoietic growth factors such as eltrombopag, etc., procoagulant drugs such as aminoacetic acid, etc., anti-infective drugs such as amoxicillin, cephalosporin, etc., hepatoprotective drugs such as compound glycyrrhizic acid glycosides, etc., or consider hematopoietic stem cell transplantation. 2. Hypersplenism: in severe cases, it can be treated by splenectomy. 3. Primary immune thrombocytopenia: glucocorticoid (prednisone), gammaglobulin, rituximab, platelet and red blood cell transfusion should be given, and surgery should be considered if the treatment effect is unsatisfactory or the condition is serious. 4. Leukemia: chemotherapy is needed, such as acute myeloid leukemia to be a cytarabine, Zoerythromycin and other drugs chemotherapy. Platelets suddenly low to 14 × 10 ⁹ / L patients, it is recommended to consult a doctor in a timely manner, scientific examination and treatment in accordance with the doctor’s instructions, to avoid unauthorized use of drugs.