The fourth generation of dipyridamole antihypertensive drugs, which can also be called the fourth generation of calcium antagonists, the main drug is cilnidipine, which is ideal for lowering blood pressure, has a mild onset of action, long-lasting effect, and has less effect on heart rate. Diphenhydramine antihypertensive drugs are calcium antagonists of the dihydropyridine class, and there are currently 4 generations, the 1st generation mainly consists of nifedipine, the 2nd generation consists of felodipine, the 3rd generation consists of lasixidipine and amlodipine, and the 4th generation consists of cilnidipine. The 4th generation, cilnidipine, effectively blocks L- and N-type calcium channels causing vasodilatation and producing a hypotensive effect. After the drug into the blood, the onset of action is slow and long-lasting, the antihypertensive effect is ideal, but also has the effect of inhibiting sympathetic excitation, which can better control the vasodilatation reflex caused by the side effect of accelerated heart rate. Long-term oral antihypertensive drugs should be under the guidance of a doctor, do not blindly take the drug, long-term drug may appear edema, facial flushing and other side effects, such as intolerance should be promptly consulted.