Agnosia is a clinical condition in which one is unable to recognize body parts and familiarize oneself with objects through organs in the absence of sensory insufficiency, mental deterioration, confusion, and inattention. It includes the absence of visual, auditory, tactile and body part recognition. How to diagnose anosognosia? 1. Cerebrovascular disease (cerebravasculardisease): The occipital lobe and temporal lobe are mainly supplied with blood by the middle cerebral artery, the posterior cerebral artery and its branches. Relevant arterial occlusion can cause the corresponding clinical manifestations, the scope of the lesion is limited before the emergence of typical simple anosognosia. However, apraxia is often more extensive and is usually secondary to stroke, with other clinical manifestations of middle cerebral artery disease. Apraxia can be detected in cerebral infarction, cerebral arteritis, cerebral branch a vein malformation and other diseases. Brain tumor (intracranialtumour): occipital lobe tumors are mostly glioblastoma, sometimes astrocytoma, with central hemianopsia and hallucinations. When the lesion is in the dominant hemisphere, there may be sensory aphasia, dyslexia, color dyscognition, and simultaneous dyscognition. Involvement of the nondominant hemisphere is associated with prosopagnosia and visuospatial agnosia. Temporal lobe tumors are asymptomatic in the early stage, and temporal lobe seizures, mainly psychomotor seizures, may occur with the progression of the disease. There are contralateral ipsilateral ¼ visual field defect and auditory agnosia, and primary involvement may cause sensory aphasia. Parietal lobe tumors are mostly metastatic, and the clinical manifestations are mostly sensory deficits, which may be complicated by sensory ataxia, hypotonia, muscle atrophy and tactile inattention. Involvement of the non-dominant hemisphere may be associated with dysesthesia and dysesthesia of the own senses. Gerst-mann’s syndrome may occur in primary involvement. Trauma: Cerebral contusion and intracranial hematoma occurring in temporal, parietal and occipital lobes can cause anosognosia. 4, intracranial infection (intracranialinfection): ear-derived brain abscess accounts for more than half of all brain tumors, the vast majority of which are located in the middle and lower temporal lobe, or cerebellar hemisphere anterior, lateral part. Hematogenous infections are more common in arterial end-supplying areas, and anosognosia may be present in all neurologic focal symptoms. Patients may have primary foci such as paranasal sinuses, middle ear, mastoid, cranial infections, lung abscesses, pyothorax, or congenital cyanotic heart disease. Fever may be present at the beginning of the disease, with increased granulocytes and proteins in the peripheral blood, and CT has a confirmatory value. Other diseases such as encephalitis, neurosyphilis, brain parasites can also cause anosognosia. 5.Others：pick disease is a kind of cerebral degenerative disease, the early stage of personality, emotional will disorder as the main symptom, intelligence loss is not obvious. In the late stage, mental decline, lack of initiative, inarticulate, less mobile, generalized failure and even death. The duration of the disease ranges from several to several decades. It is difficult to differentiate from Alzheimer’s disease. There are data confirming that patients have increased zinc concentration in the brain. Urinary zinc excretion is also increased. In the early stages of the disease, the intellectual decline is less severe and may be characterized by visual cognitive deficits, or somatosensory deficits may be detected. Alzheimer’s disease, carbon monoxide poisoning, etc. may also detect anosognosia.