If you have gallstones and you still have pain, it may be due to larger stones, inflammation or gallbladder contraction. 1. larger stones: for larger gallstones, the simple use of painkillers can only treat the symptoms but not the root cause, even if the infusion of painkillers, can not be completely cured, and then the symptoms may reappear. 2. Combined inflammation: most gallstones patients will be combined with cholecystitis, stimulated by inflammation will also cause pain, so simple pain relief can not relieve the symptoms, but also need to be combined with antibiotic anti-infection treatment, such as cefuroxime, penicillin and so on. 3. gallbladder contraction: gallstones appear embedded in the neck of the gallbladder, the gallbladder contraction of bile can not be discharged, will also cause biliary colic, even if the infusion of pain relief, can not be controlled. If gallstones are still painful through infusion of pain relief, it is recommended to consult a doctor in a timely manner, and according to the judgment of a professional physician to understand the cause before treatment, to avoid unauthorized use of drugs to cause discomfort and delay the condition.