Cramps in the hands and legs are considered to be caused by calcium deficiency, epilepsy, hypoglycemia, catching cold, and insufficient blood supply to the brain. 1. Calcium deficiency: usually caused by insufficient calcium intake, causing increased nerve excitability and muscle twitching, symptoms can be relieved by calcium supplementation. 2. Epilepsy: When epileptic seizures occur, the hands and legs cramp, accompanied by foaming at the mouth, can be relieved by themselves. Electroencephalogram (EEG) can be done to make a clear diagnosis. 3. Hypoglycemia: When hypoglycemia occurs, it can cause coma and cramps in arms and legs. 4. Cold: when feeling wind-cold, it can cause muscle contraction of arms and legs and cramps, which can be relieved after keeping warm. 5. Insufficient blood supply to the brain: when the brain is not enough blood and oxygen can cause cramps in the arms and legs. Cramps in the hands and legs need to go to the hospital for further examination to clarify the cause of the disease and follow the doctor’s instructions for treatment.