When gastrointestinal mesenchymal tumor recurs and metastasizes to the lungs can be treated with radiotherapy or targeted therapy to improve the symptoms, and the treatment needs to be carried out under the guidance of doctors. After the recurrence of gastrointestinal mesenchymal tumor with lung metastasis, standardized radiotherapy and targeted therapy can shrink the lesion, kill some tumor cells, slow down the disease progression, and improve the patient’s quality of life. The chemotherapeutic drugs that patients can choose include cisplatin, cytarabine, paclitaxel, etc.; targeted drugs include sunitinib, imatinib, regorafenib, etc.. Since there is no absolute most effective and safest drug, it needs to be used in strict compliance with the doctor’s instructions, the emergence of adverse reactions to timely consultation, drug allergy is prohibited. After actively cooperating with doctors to receive standardized treatment, can significantly improve the prognosis of the disease.