Thick endometrium in menopause may be endocrine disorders, endometrial hyperplasia, endometrial cancer, etc., which can be treated with medication, surgery, and radiotherapy if necessary. 1. Endocrine disorders: the hormone level in the body is disturbed when entering menopause, and estrogen is fluctuating, which can be treated with drugs such as progesterone and medroxyprogesterone, and the endometrial lining will become thinner after menstruation in general. 2. Endometrial hyperplasia: prolonged estrogen stimulation without progesterone resistance leads to endometrial hyperplasia, which can be treated with oral progesterone drugs, such as medroxyprogesterone acetate and dydroxyprogesterone, and for those who do not have any obvious relief after 12 months of treatment, they can undergo surgical treatment, such as total hysterectomy. 3. Endometrial cancer: malignant tumor of endometrial epithelium, the uterus, bilateral fallopian tubes, ovaries and so on can be removed through surgery, and radiotherapy can be carried out after surgery. Thick endometrium in menopause should communicate with doctor in time, do further examination, make clear diagnosis, target treatment, if need to use medicine should strictly follow the doctor’s prescription.