In addition to abdominal pain, chills, fever, jaundice and other symptoms associated with acute obstructive suppurative cholangitis, patients with Reynaud’s pentad is also suffering from infectious shock and psychoneurological symptoms. In this case, the patient is considered to have central nervous system changes due to acute obstructive septic cholangitis, and requires active hospitalization, otherwise there is a possibility of further hepatic encephalopathy or infectious shock or death due to liver failure. In such cases, the patient should first be actively considered for anti-inflammatory treatment with intravenous infusion of broad-spectrum antibacterial drugs. Secondly, decompression of the biliary tract should be actively considered, and PTCD puncture and drainage, as well as placement of a nasobiliary tube under ERCP for further drainage, and removal of bile duct stones, if any. The patient will recover in about 5-10 days after active treatment. After internal or external drainage, some bile should be taken for bacterial culture, and sensitive antibiotics should be replaced according to the results of bacterial culture and drug sensitivity test, and active anti-inflammatory treatment should be given.