Alpha-fetoprotein that fluctuates within the normal range is usually normal and not serious. Alpha-fetoprotein is a glycoprotein included in the albumin group, and its normal value is usually <25 mg/L. It is commonly used clinically as an aid in the diagnosis of primary hepatocellular carcinoma. Clinically, it is believed that if serum alpha-fetoprotein is over 400mg/L and persistently elevated, and if gonadal germinoma, pregnancy and active liver disease can be excluded, it can be suspected to be primary hepatocellular carcinoma, and then the diagnosis can be further clarified by CT enhancement or hepatic puncture biopsy. There are many diseases that cause elevated alpha-fetoprotein, such as elevated alpha-fetoprotein in childhood, which may be hepatoblastoma; viral hepatitis or cirrhosis can also cause elevated alpha-fetoprotein, and the degree of increase is positively correlated with the degree of hepatocyte necrosis and regeneration; in addition, benign liver disease may also have elevated alpha-fetoprotein, which lasts for a shorter period of time, while malignant lesions, which last for a longer period of time. Therefore, dynamic monitoring of alpha-fetoprotein can identify benign and malignant diseases and diagnose early hepatocellular carcinoma. In addition, alpha-fetoprotein is also effective in monitoring the recurrence of hepatocellular carcinoma after surgery. If abnormal increase of alpha-fetoprotein occurs, please go to the hospital in time.