The prevalence of diabetes mellitus has gradually increased in recent years, with a corresponding increase in various chronic complications, and diabetic acromegaly is a common and serious complication that progressively affects large and medium-sized microvascular and neurological lesions in the limbs. The incidence has been reported to be about 0.9%-1.7% of diabetic patients in China. Its clinical characteristics are end limb pain, infection, ulceration and gangrene. Once the disease occurs, it is fast developing, heavy and difficult to treat, and the rate of amputation is about 40 times that of non-diabetic patients. It becomes one of the important causes of disability and death of diabetic patients. At present, China adopts the combination of Chinese and Western medicine treatment, so that the amputation rate of this disease from the past 38.1%-75.8% to 4.2%, the cure rate of 87.5%, fully reflects the advantages of the combination of Chinese and Western medicine treatment of this disease. This disease belongs to the category of “thirst and gangrene” in Chinese medicine. As early as the Song Dynasty, there is a record in the “Health Treasures” that “patients with thirst develop malignant sores on the feet and knees, resulting in death without rescue. It is generally believed that the etiology of this disease is due to Qi and Yin deficiency, heat and toxin stasis blocking the blood vessels and loss of nourishment of the extremities. The deficiency of qi and yin in the thirst is the root cause, and the loss of nourishment of the extremities due to heat and toxin stasis of blood is the symptom. Based on this, the author summed up some previous clinical results to control blood glucose as the premise of treatment, anti-infection, clearing heat and detoxification, activating blood circulation and resolving blood stasis to treat its root, received better results, is introduced as follows: Treatment 1, active control of diabetes 1.1 strict control of diet 1.2 insulin intensive treatment program to control blood glucose 2, internal treatment 2.1 active anti-infection, select sensitive antibiotics intravenous drip 2.2 anticoagulation, Improve microcirculation, activate blood circulation and remove blood stasis treatment. IV antithrombin, scopolamine, chuanxiongzine, oral pancreatic kinase tablets. 3.External treatment Routine disinfection and rinse the wound surface with hydrogen peroxide and saline. After the wound surface is cleaned, infiltrate with compound salvia injection and sensitive antibiotic solution, then apply Marble powder externally to expose the wound surface and change the medicine once a day. A typical case Wang, male, 43 years old, a worker, was admitted to the hospital on March 5, 1996 with “excessive drinking and urination for 9 years and skin ulceration of both feet for 2 months”. On examination: the dorsal arterial pulsation of both lower extremities was weakened. 2.0×3.0M2 of the dorsal part of the right foot and 3.0×8.0M2 of the heel were seen; 1.0×2.0M2 of the toe end and 3.0×15.0M2 of the heel of the left foot had skin ulceration, and purulent secretions were visible. After admission, he was given strict diet control, insulin intensive treatment program to control blood glucose, static penicillin, antiembolism, scopolamine, chuanxiongzine, oral pancreatic kinase tablets, and external application of penicillin powder to the trauma, followed by wet application of bupropion to the trauma for more than 1 month according to the results of the trauma secretion culture. The trauma was infiltrated and topical Marble powder was applied, and the dressing was changed once a day after exposure. The treatment of diabetic acrodynia is very difficult, and for many years, surgical high amputation has been used for severe acrodynia, resulting in lifelong disability. In recent years, some progress has been made in the conservative medical treatment in China, and the results are promising. With reference to some domestic literature reports in recent years, the combination of Chinese and Western medicine has a broader prospect for treatment. In the case of this paper, the patient started to take Western medicine treatment, although both internal and external treatment, but the local tissue blood transport is poor, healing is slow, while the trauma surface with the addition of Danshen and Marble powder, the medicinal power directly to the disease, so only 1 week the trauma surface healed, reflecting the advantages of using Chinese medicine treatment. Salvia miltiorrhiza, bitter in taste and slightly cold, activates blood circulation, cools the blood and relieves pain, and nourishes the blood and calms the mind. It is recorded in “The Materia Medica of Nihua Zi” that it “nourishes the mind and determines the will …… to drain pus and relieve pain, and to produce muscle and flesh”, which has the effect of removing blood stasis and producing new blood. Mab, pungent and flat, clears the lung and throat, detoxifies and stops bleeding. It was first recorded in the “Famous Doctor’s Record” as “Mainly used for malignant sores and horse scabies”, and in the “Materia Medica Preparation” as “Clearing the lungs and relieving heat, dispersing blood and stopping coughs, treating laryngeal paralysis and sore throat …… and applying it externally to all sores”. Modern pharmacological research is consistent with the efficacy of the ancient herbal records, pharmacology shows that this product has a certain inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis and Diplococcus pneumoniae. It does not need high temperature disinfection and is applied directly to the wounds externally without sticking when moistened. The first reported in China is Yangliu Hong treatment of 2 cases were satisfactory results, while the combination of Danjin with Mab for the treatment of this disease has not been reported in China. The author believes that the combination of the two drugs has a synergistic effect of anti-inflammatory and pain relief, improving microcirculation, correcting hypercoagulability, increasing local tissue blood supply, improving skin nutrition and promoting tissue repair of the trauma; on the other hand, it is easy to use, economical and practical, suitable for promotion and application in primary hospitals, and the efficacy is satisfactory. Of course, there are still some problems to be solved in the actual clinical application, such as the small pus cavity, Marble powder is not easy to fill, for dry gangrene effect is not good, etc.. Since the incidence of this disease is relatively low and the number of cases is limited, we still need to learn from our peers in the course of future clinical practice to continuously summarize and verify in order to expect better results.