Gastrofluan, also known as methotrexate, is a treatment for gastrointestinal symptoms such as nausea, vomiting and belching. Its toxicity is very low, and only about 1% of patients taking Gastrofluan in the general population will experience toxic reactions. However, it is different for the elderly and patients suffering from metabolic disorders (e.g. diabetes). They are prone to neurological adverse effects, mainly acute dystonia with paroxysmal episodes. The adverse reactions caused by Gastrofluan are very complicated, with odd and variable demeanor at the onset, resembling some manifestations of hysteria, epilepsy, neurosis, tetanus and other diseases, so it is easy to misdiagnose. In view of the decline of the body function of the elderly, metabolic function is lower than that of young people, taking gastroflucan is easy to develop, so the elderly should avoid using gastroflucan to prevent unpredictable. If the elderly have nausea and vomiting, use one of the drugs such as vitamin B6, scopolamine, belladonna combination or vertigo stop as appropriate, and find out the cause of nausea and vomiting as soon as possible.