The difficult-to-cure skin diseases are as follows: 1. Erythema scales skin diseases, including psoriasis and neurodermatitis. The treatment of psoriasis can be taken orally with compound amineptin tablets and compound glycopyrrolate tablets, and topical application of carbotriol ointment, tacalcitol ointment, glucocorticoid ointment, such as hydrocortisone butyrate ointment, dextran ointment, fluticasone propionate cream, halometasone ointment. For neurodermatitis, mainly oral levocetirizine hydrochloride capsules, olopatadine hydrochloride tablets, avastin tablets, and also topical application of glyburide lotion, hydrocortisone butyrate ointment. 2. are herpetic skin diseases, including aspergillosis and herpetiform aspergillosis. 3. abnormal skin diseases of the body’s immune system include lupus erythematosus as well as dermatomyositis, systemic scleroderma. 4. allergic diseases, such as eczema, atopic Allergic diseases such as eczema, atopic dermatitis, etc.