Red dots in the penile groove may be pearly papules, condyloma acuminatum, genital herpes, etc. 1. Pearly papules: may be caused by long foreskin, poor personal hygiene, infection of the coronal groove of the foreskin and so on. The patient’s penile groove may appear red spots, i.e. red papules, and pearly. 2. Condyloma acuminatum: It is mainly caused by human papillomavirus. When warts appear in the penile trench, the lesions are initially single or multiple scattered reddish pimples, i.e. red dots, and are soft in texture and sharp at the tip. 3. Genital herpes: mainly caused by herpes simplex virus infection of urogenital and perianal skin mucosa. The patient’s lesions may appear red spots, that is, red blisters, can also be accompanied by pain. It is recommended that patients go to the hospital in a timely manner, and follow the doctor’s instructions for treatment to avoid delaying the condition.