Gray color of esophagus may be a normal physiological phenomenon, or it may indicate esophageal mucositis and other diseases. 1. Normal phenomenon: the normal color of esophageal mucosa is pink, and the lower esophageal mucosa can be slightly light gray, gradually junction with gastric mucosa, accompanied by longitudinal folds, which is a normal performance. 2. Disease manifestation: If the esophageal mucosa has focal gray color change, it suggests that the possibility of disease is higher, such as esophageal mucositis, esophageal pre-cancerous lesions, esophageal melanoma, etc. It is necessary to determine the nature of the lesion through pathological examination. If color changes are found in the esophagus, further examination should be conducted under the guidance of a doctor in a timely manner and should not be ignored in order to avoid delaying the condition.