Numbness in the hands while sleeping can be a sign of stroke or a sign of numbness due to nerve compression. Strokes are most common in middle-aged and elderly people, who are prone to ischemic strokes due to the slowing down of blood flow during sleep. When the blood vessels are occluded, the person can experience symptoms of neurological deficits, such as numbness of the hands, and in severe cases, numbness of one side of the limb. Treatment mainly focuses on improving blood circulation and promoting nerve function recovery. Numbness of the hand while sleeping can also be caused by nerve compression, which is clinically more common in cervical spondylosis. Due to the compression of the nerves by the herniated cervical intervertebral discs during sleep, numbness of the hands and, in severe cases, weakness of the hands can occur, which can be diagnosed by CT examination of the cervical intervertebral discs. Elbow and carpal tunnel syndromes can also cause nerve compression, and the patient may also experience numbness in the hands, which can be confirmed by an electromyogram if necessary.