The remittent crisis usually appears in the course of chronic hemolytic anemia, mostly in the presence of infectious factors, and resembles the clinical manifestations of aplastic anemia, including anemia, hemorrhage, and hemolysis. However, it is a transient disease with a duration of about 1-2 weeks, mostly associated with infection to microvirus B19. The prognosis is relatively good, and in hereditary spherocytosis, diseases such as severe malnutrition can also present similarly to remitting crisis. Recent studies have concluded that remitting crisis is mainly related to infection with human microvirus B19, which can inhibit the growth of red lineage hematopoietic progenitor cells, inhibit colony formation and proliferation of red lineage cell-forming units, and inhibit red blood cell growth, leading to clinical manifestations such as anemia and hemorrhage. Treatment consists mainly of avoiding trauma and infection, treating the cause of the disease, and supportive therapy. The prognosis is relatively good, lasting 1-2 weeks with gradual resolution of symptoms and normalization of hematological changes.