Bile reflux and periumbilical flatulence suggest the presence of dyspepsia and peptic ulcer, which can be treated with probiotics, omeprazole, mosapride, and other medications under the guidance of a physician, or surgically if necessary. Dyspepsia is a functional disease. When the intestinal flora is imbalanced and gastrointestinal motility is poor, bile reflux and periumbilical flatulence may occur. At this time, treatment with probiotics or gastric stimulants, such as Bifidobacterium bifidum and Mosapride, is needed. Peptic ulcer tends to cause gastrointestinal peristalsis, bile reflux and periumbilical flatulence. Treatment with acid suppressants such as omeprazole and gastric mucosal protectants such as aluminum thioglycollate is required. In addition, it may indicate the presence of biliary tract disease. When the patient’s symptoms of bile reflux and periumbilical flatulence continue to be unrelieved, it is recommended that the patient seek medical attention in a timely manner and under the guidance of a doctor to carry out standardized treatment and avoid unauthorized use of drugs. The above medications should be used under the guidance of a medical professional.