Diabetes belongs to the category of “thirst” in Chinese medicine. According to Chinese medicine, the main pathogenesis of thirst is Yin deficiency, dryness and heat, and damage to the internal organs. The treatment requires nourishing Yin and moistening dryness, clearing heat and quenching thirst. The main effect of Dendrobium is to nourish Yin and clear heat, moisten dryness and quench thirst, and the treatment of thirst with Dendrobium is in line with the theory of traditional Chinese medicine, with reasonable identification and the right medicine. Modern medical research shows that Dendrobium can both increase insulin secretion and improve insulin resistance, which has a direct hypoglycemic effect on diabetes and can also improve the complications of diabetes. Dendrobium also has the effect of improving immunity, which is very effective in treating diabetes, and it will be more effective when used with Chinese herbs such as maidenhair, smallpox powder, yucca and geranium.