Sitting for a long time knee pain may be the lack of movement of the knee joints caused by normal physiological phenomena, but also may be caused by knee arthritis, rheumatoid arthritis and other diseases, according to the cause of the disease to take medication, surgical treatment, general treatment and other therapeutic measures. 1. Lack of exercise: knee pain after sitting for a long time may be caused by muscle stiffness due to lack of movement in the knee joint, it is recommended to move the knee appropriately, you can also carry out appropriate exercises, such as walking, brisk walking, playing Tai Chi, etc., can alleviate the symptoms of discomfort. 2. Knee arthritis: knee arthritis patients will appear knee pain, limited activity, joint deformity and other symptoms, the patient can follow the doctor’s instructions oral celecoxib capsules, Erythroxib capsules and other non-steroidal anti-inflammatory drugs, but also can be injected with sodium vitreous acid injection, hydrocortisone sodium succinate injection, such as intra-articular cavity injection of drugs. If necessary, surgical treatment can also be taken, such as arthroscopic cleaning, osteotomy, joint fusion and other surgical methods. 3. Rheumatoid arthritis:The main symptoms of rheumatoid arthritis are joint pain, redness and swelling, etc. Patients can take oral aspirin tablets, diclofenac sodium extended-release tablets and other non-steroidal anti-inflammatory drugs. It can also be treated with penicillin, using injectable benzylpenicillin for treatment. The symptoms of knee pain after sitting for a long time may also be caused by other diseases such as meniscus injury, synovitis, etc., which should be promptly consulted and treated according to medical advice.