The rate of antinuclear antibody 1:100 conversion is unclear and cannot be generalized; antinuclear antibodies are autoantibodies, and on the basis of antinuclear antibody 1:100, the titer may continue to rise, or it may stabilize, or it may become negative. Antinuclear antibodies 1:100 alone are of little diagnostic significance clinically, and can be seen in the elderly and in women, as well as with the effects of certain medications (e.g. procainamide, etc.). In most cases, no special treatment is needed, so when an antinuclear antibody index of 1:100 is detected and the value is stable and does not continue to rise, no treatment can be taken for the time being. After that, it is necessary to observe the situation regularly. If the antinuclear antibodies are gradually rising, it is usually indicative of connective tissue diseases, such as lupus erythematosus, dry syndrome, systemic sclerosis, etc., and the higher the value, the higher the risk, and the difficulty of treatment will be increased, as autoimmune diseases are not able to be cured on their own at the present time. Therefore, it is recommended to observe the anti-nuclear antibody level of 1:100 on a regular basis. If you find that the level is gradually increasing, you should consult your doctor and analyze the cause of the disease through a professional examination before treating the symptoms.