Lung adenocarcinoma m277e mutation treatment can be done by surgery, radiotherapy chemotherapy combination therapy and drug therapy. 1. Lung adenocarcinoma is generally staged according to TNM staging standard, T means tumor condition, N means whether lymph nodes are metastatic or not, and M is metastasis to distant lymph nodes and organs.T1 and T2 mean that there is no spreading of tumor cells, N0 means no lymph node metastasis, and M0 means no distant metastasis. 2. Treatment: The first choice of treatment is surgical resection, which is lobectomy plus mediastinal lymph node dissection. Radiotherapy and chemotherapy are also available. Patients with advanced stage are mainly treated with medication, which is currently divided into chemotherapy and targeted therapy. Targeted therapy drugs can use EGFR class, such as ositinib and so on. The patients should be rechecked on time and insist on long-term follow-up. If previous symptoms worsen or new symptoms appear, they need to consult a doctor in time.