A high albumin-to-globulin ratio usually means that liver function is synthetically impaired, while immune function is upregulated. The albumin-to-globulin ratio is an important indicator of the body’s nutritional status, while globulin is a growth indicator of the body’s immune system. Normally, albumin is higher than globulin, with the normal figure at 1.5-2.5 times. If the albumin-to-globulin ratio is reduced or even inverted, it indicates that the patient’s liver function is damaged to some extent, such as infection with hepatitis or long-term heavy alcohol consumption and drugs that cause liver function damage, resulting in liver synthesis dysfunction. At this time, the body will appear protective mechanisms, the ratio of liver synthesis of globulin began to rise, the immune response also gradually appear, as manifested in the AG ratio decreased or even inverted. The AG ratio can gradually return to normal after the liver function status is restored through liver protection and hepatoprotective treatment.