The inability of full-term newborns to get rid of oxygen may be due to congenital heart disease, or it may be caused by other diseases such as ischemic-hypoxic encephalopathy and severe pneumonia. 1. Congenital heart disease: children with congenital heart disease due to tetralogy of Fallot, ventricular septal defect and other reasons can lead to the flow of blood from the right cardiac vein into the circulation, resulting in hypoxia, respiratory distress, persistent bruising of the skin and a series of other symptoms, such children need to be on continuous oxygenation, and may also require surgical treatment. 2. Ischemic-hypoxic encephalopathy: Ischemic-hypoxic encephalopathy is due to various reasons resulting in ischemic-hypoxic changes in the brain tissue of the child, in the early stages of the disease need to ensure that the child has good ventilation, ventilation function, and therefore can not be deoxygenated, and in the recovery period should be used in the use of hyperbaric oxygen in order to reduce the damage to the tissues. 3. Severe pneumonia: During labor and delivery, the fetus inhales a large amount of amniotic fluid, which can lead to severe pneumonia, which in turn causes respiratory distress, thus also requiring assisted breathing. In addition to the diseases listed above, other diseases may also cause newborns to require continuous oxygenation. Each child’s condition is different, so please consult your doctor for specific treatments.