Prednisone shock therapy is a hormonal therapy using 10-20 times larger doses than conventional doses, applied for a short period of time, for acute renal failure due to acute progressive glomerulonephritis, lupus nephritis, and other diseases with a significant immune response. Acute progressive glomerulonephritis is due to acute severe immune inflammatory reaction in the kidney, which damages the kidney and causes a drastic decrease in blood flow and then acute renal failure. It is mainly manifested by a sharp increase in creatinine and urea nitrogen, and the symptoms may include little or no urine, nausea, vomiting, elevated blood pressure, and swelling. At this time, hormone shock therapy such as prednisone is given. High-dose hormone therapy can improve kidney inflammation, block further deterioration of kidney function, prevent fibrosis of glomeruli, and then make kidney function improve or even recover. After the disease is stabilized, it is changed to regular dose hormone therapy.