Dry syndrome (SS) is a chronic inflammatory autoimmune disease mainly involving exocrine glands, also known as autoimmune exocrine gland epithelial cellulitis or autoimmune exocrinopathy. In addition to dry mouth and eyes due to decreased function of salivary glands and lacrimal glands, SS also involves other exocrine glands and other organs outside of the glands, resulting in multisystem damage and, in many patients, serious complications such as interstitial lung fibrosis and cirrhosis. The serum has a variety of autoantibodies and hyperimmunoglobulinemia, the most classic of which are anti-SSA and SSB antibodies. The disease is divided into two categories: primary and secondary. Primary dry syndrome is a global disease, the prevalence of which is 0.3% to 0.7% in our population, and 3% to 4% in the elderly population. The disease is more common in women, the ratio of men to women is 1:9～20. The age of onset is mostly 40～50 years old. It is also seen in children. Dry syndrome can involve the mucous membrane of nose, larynx, trachea and bronchus, resulting in reduced mucus secretion. More than half of the patients have dry nasal nodules, nasal blockage, mucosal atrophy and olfactory inability. A few patients may have nasal septum perforation. 80% of patients have dry and painful throat, hoarse voice, dry cough, sticky sputum that cannot be easily coughed out, chest tightness and shortness of breath. Some patients show bronchitis, bronchiectasis, interstitial pneumonia, and diffuse pulmonary fibrosis, which is often easily combined with infection and the infection is difficult to control. In the late stage of pulmonary fibrosis, pulmonary hypertension and pulmonary heart disease may occur, and dyspnea and lower limb edema may appear. More than 70% of patients with desiccation syndrome have respiratory function changes, manifesting as small airway obstruction. x-ray chest abnormalities vary depending on the length of medical history, and about 50% of patients have interstitial lung changes. Lung CT can show early alveolitis, fibrous alveolitis, pulmonary fibrosis changes, lung damage in desiccation syndrome is a chronic process, when patients have respiratory symptoms during the course of the disease, lung examination should be carried out, early treatment and prevention of infection. There are also many rheumatic immune diseases such as rheumatoid arthritis, systemic sclerosis, inflammatory myopathy, lupus erythematosus, etc. Pulmonary complications can occur, so patients who often have unexplained lung lesions are advised to visit the rheumatology clinic to exclude rheumatic immune diseases. Oral dryness is the most significant clinical manifestation of dryness syndrome, and it is heavier at night. Patients often have difficulty in sleeping, chewing, swallowing, and even pronunciation in serious cases due to frequent drinking, oral mucosa congestion, food adhesion and retention, tongue cracking, smell and taste loss or disappearance, and saliva reduction not only makes the cleaning function of oral cavity low, but also inadequate supplementation of calcium and phosphorus to teeth. Therefore, the incidence of dental caries is very high. A few patients have difficulty in swallowing due to narrowing of the esophagus after the cricoid cartilage or abnormal function of the esophageal muscles, and even drinking a lot of water cannot improve the symptoms. 3, stomach Mainly manifested as epigastric discomfort, pain, nausea, vomiting and other indigestion symptoms, gastroscopic chronic superficial, hypertrophic and atrophic gastritis of different characteristic changes, and the latter onset is the majority. A group of 44 cases of dry syndrome in China reported that chronic atrophic gastritis accounted for 70.5%, and those with low gastric acid and no gastric acid secretion accounted for 36.4% and 13.6% respectively. 4.Large intestine and small intestine Unlike other digestive organs, there are not many opportunities for intestinal involvement in patients with desiccation syndrome, and the mechanism is not yet understood. Atrophy of the jejunal villi and a decrease in their number are the main histological changes. 5, liver, bile The liver lesions in patients with dry syndrome are mainly liver enlargement (25%-28%) and elevated alkaline phosphatase (25%-33%), and pathological biopsy can show the manifestation of primary biliary cirrhosis, or chronic active hepatitis. Primary biliary cirrhosis and dry syndrome have certain correlation, about 3/4 of patients with primary biliary cirrhosis have dry symptoms, 33%-47% of them have typical dry syndrome in combination; and 7%-13% of patients with dry syndrome have positive anti-microsomal antibodies, which also suggests that primary dry syndrome is closely related to primary biliary cirrhosis. However, patients with primary biliary cirrhosis rarely have anti-SSA and anti-SSB antibodies in their bodies, and their dryness symptoms may be the manifestation of secondary dryness syndrome. 6, pancreas The pancreas and salivary gland have many similarities in terms of anatomy, physiology and pathology …… There are more chronic pancreatic lesions in patients with desiccation syndrome than acute ones. Malabsorption syndrome (steatorrhea, pseudo-intestinal paralysis, cachexia) occurs in a few cases and can even lead to death.