Urine protein high blood creatinine normal, generally considered to be glomerular and tubular diseases, metabolic diseases, physiological factors, need to be based on the cause of the cause of treatment such as oral prednisone acetate, cyclophosphamide, dagliflozin, etc., and at the same time need to eat a light diet, regular rechecks. 1. Glomerular and tubular diseases: It may be caused by glomerular and tubular diseases, such as primary glomerulonephritis, systemic lupus erythematosus nephritis, allergic purpura nephritis, primary small vessel vasculitis kidney damage, etc. Generally, hormone therapy is needed to inhibit immune response, such as prednisone acetate, and immunosuppressant drugs, such as cyclophosphamide, can be used. 2. Metabolic diseases: such as hyperuricemia kidney damage, obesity-related nephropathy and diabetic nephropathy, etc., which need to receive uric acid, blood pressure and glucose-lowering treatment, such as febuxostat tablets, dagliflozin, valdecoxib capsules and so on. 3. Physiological factors: such as large amount of high-protein diet, strenuous exercise, fever, etc., need to pay attention to rest, light diet, regular review. In addition, the application of the above drugs, all have certain risks, patients need to take under the guidance of a specialist. There are many other reasons for high urinary protein and normal creatinine, such as urinary tract infections and urinary stones. It is recommended that patients consult a regular hospital in a timely manner, under the guidance of a physician standardized treatment.