Children with Tourette Syndrome experience frequent blinking, which does not usually cause pupil size inequality. Tourette’s syndrome mainly involves one or more muscles, resulting in muscle twitching. It is common in children, and the most common typical symptom of children with Tourette’s syndrome is transient tic disorder, which mainly manifests as blinking, shrugging of the nose, wrinkling of the forehead, sideways glances, opening of the mouth, shaking of the head, shrugging of the shoulders, and slanting of the neck, etc., but it does not usually cause pupil size inequality. The causes of unequal pupil size mainly include eye diseases, such as keratitis, iritis, ciliary body inflammation, and neurological diseases, such as traumatic brain injury, cerebrovascular disease, polyneuritis. It is recommended that children with Tourette’s syndrome consult a doctor to evaluate their condition and develop an appropriate treatment plan under the doctor’s guidance.