AIDS itself does not cause peeling of the hands and feet, but due to the patient’s immune deficiency, AIDS can often be combined with a variety of diseases and manifested as peeling of the hands and feet. The acute and asymptomatic stages of AIDS usually have no specific manifestations, and generally do not lead to peeling of the hands and feet. During the AIDS period, due to the massive replication of the virus, the body’s immune function is low, often combined with herpes zoster, human papillomavirus, fungal dermatitis, onychomycosis and other infections and tumors and other diseases, manifested by the corresponding symptoms of the disease, there may be peeling of the skin on the hands and feet. To summarize, AIDS will lead to different parts of the body with different degrees of peeling due to the complication of a variety of diseases, the specific symptoms are determined by the complication of the disease, which can occur alone, or a variety of diseases occur at the same time.