Itchy soles of the feet, especially at night, this condition may be caused by allergies, or it may be formed by local eczema, especially chronic eczema. Therefore, for this condition, when treating it, local medication is usually the main focus, and at the same time, oral antihistamine medication is needed.1. Topical medication: you can apply topical tretinoin econazole cream, or you can also apply other anti-itch medication, such as dandruff cream or Chinese medicine old stork grass cream, etc. While applying anti-itch drugs, you also need to use nourishing drugs, such as urea cream, etc. 2. Oral drugs: You can generally choose second-generation antihistamines, such as levocetirizine hydrochloride, loratadine or epalrestine, etc. It can also be taken orally with traditional Chinese medicine, such as moistening and anti-itching capsules or anti-feng and anti-itching granules, etc..