Treatment of diabetes mellitus

  Along with the prevalence of over-nourished, under-exercised and brain-drained lifestyles and unnamed causes such as environmental pollution, the high prevalence of diabetes is increasingly coming to the forefront of public society. Diabetes can be encountered in all aspects of medical care: high blood sugar is often found during health check-ups, coronary heart attacks or hypertensive stroke hospitalizations are compounded by high blood sugar, diseases requiring surgical treatment cannot be performed as scheduled because of high blood sugar, and gestational diabetes frequently affects mothers-to-be. Even laypeople whose jobs are not related to medicine can feel the proliferation of advertising for diabetes medications, foods and supplies. Although the treatment of diabetes is widespread and the principles of diabetes diet, exercise, medication and monitoring go hand in hand, it is generally accepted by doctors and patients alike. However, the details of treatment for diabetic patients vary greatly depending on their current condition, blood glucose level, previous treatment, age of onset, length of history, weight, accompanying diseases, and many other circumstances, which in turn bring about a very different quality of life and life for diabetic patients. The right treatment can significantly improve the fate of the patient, while inappropriate treatment may be better than no treatment at all. Improving the quality of diabetic visits and providing individualized treatment for each diabetic patient as much as possible is a major technical requirement for endocrinologists.  More and more medical research proves that the prevention of chronic complications of diabetes is important, but also the early level of blood glucose control, which is called “metabolic memory” in medicine. More and more medical practice proves that the level of blood glucose control mainly depends on the residual islet function of the patients themselves. In addition to the etiology and history of the disease, the residual islet function is also very relevant to the proper measures at the beginning of glucose-lowering treatment, which is medically referred to as the “time window of islet function protection”. Stabilizing blood sugar is the core of diabetes treatment, and the most effective measure to stabilize blood sugar is to protect the residual islet function. At the current level of medicine, the effectiveness of islet function protection is limited by time. Therefore, medical professionals are paying more and more attention to and improving the treatment measures for first-time or first-treatment diabetic patients. Currently, it is generally recognized that the best initial glucose-lowering measure with islet protection is short-term insulin pump intensive therapy.  The whole insulin pump is the size of a beeper. It consists of insulin reservoir, micro drive motor, computer program, display and subcutaneous infusion catheter. It simulates the dual secretion mode of physiological insulin basal and mealtime. It can avoid the overload of its own islet cells while the blood glucose is smoothly controlled, so that the dying islet cells can rest and recuperate, and then rejuvenate. Outpatients can wear insulin pump continuously for 10-20 days with their work life as usual, and then change to normal treatment. After reinforcement with insulin pump, most of the patients can take less medication than conventional treatment, and a few patients can temporarily leave the treatment of glucose-lowering drugs, and individual patients with very poor islet function can infer the residual islet function based on the basal supplementation of insulin pump, which can help doctors to formulate a proper plan and skip the process of figuring out the dose of conventional insulin injection. Generally speaking, it is more effective for gestational diabetes, stress-induced severe hyperglycemia and obese diabetes.  Patients who have had diabetes for a long time should be treated in combination. Patients who have had diabetes for a long time often lose patience with glucose-lowering treatment and often make the treatment a mere formality. Or they think that they have been sick for a long time and choose their own drugs according to advertisements and experience. It is not known that with the development of science and technology, glucose-lowering drugs are emerging, and with the economic development, the names of drugs are being renovated. In the face of a wide range of glucose-lowering drugs, pro-secretants, potentiators, long-acting agents, short-acting agents, controlled-release agents, slow-release agents, enterosol, even general practitioners have to continue to learn the selection and application of new drugs through continuing medical education. What’s more, the islet function has been depleted for a long time, making it difficult for doctors to deal with the high and low blood sugar changes. At this time, even experienced endocrinologists have to go through a detailed understanding of the disease and a reasonable combination of multiple drugs to tame the uncontrollable blood sugar. Most patients with a history of diabetes for more than 10 years must be helped by a professional physician to develop a glucose-lowering plan, otherwise the calm and quiet blood sugar may be the creator of a troubled life in the future.  Complex diabetes should be treated in an integrated manner Two-thirds of diabetic patients often have a combination of more than 2 other diseases. Common diseases such as hypertension, hyperlipidemia, fatty liver, coronary heart disease, hepatitis B, chronic gastritis, cholecystitis, osteoporosis, depression and anxiety, stroke, Alzheimer’s disease, etc. are very common along with diabetes. They are either the accomplice or the accomplice of the tiger, making the diabetic patient suffer from a heavy burden. The simultaneous or sequential presence of multiple diseases is both etiologically related and may be triggered by improper treatment. Therefore, in the face of the coexistence of multiple diseases, how to grasp the main contradiction between diseases, grasp the interaction between different drugs, as far as possible to treat A disease at the same time to take into account B disease, control A disease also benefit B disease, to meet the medical requirements at the same time to minimize the patient’s economic costs, this kind of complex treatment, requires a comprehensive quality of doctors to grasp the overall integrated disease.  Geriatric diabetes should be treated flexibly The elderly who have endured the years begin to return to their childlike character, and the old patients who have experienced the ravages of the disease have a more fragile life. Diabetes treatment measures and goals must take into account the life-threatening effects of age. Improper drug selection, improper dosage or incorrect usage may be more damaging to life than the disease itself. It is a great desecration of life to compromise the oldest old with the improper use of medications. At this time, elderly diabetics rely more on the care of others and the careful treatment of doctors.