Adrenocortical crisis refers to the clinical symptoms caused by insufficient or lack of adrenocorticotropic hormone secretion, including the manifestations of saline corticosteroid deficiency and glucocorticoid deficiency. Its symptoms can involve multiple systems such as cardiovascular, digestive, neuropsychiatric, skin and mucous membrane, immunity, and reproduction. The main manifestations of adrenocortical crisis are 1. Salt corticosteroid insufficiency: (1) Severe circulatory collapse, dehydration, drop in blood pressure, upright syncope, and shock. (2) Metabolic acidosis, hyperkalemia, circulatory failure. 2. Insufficient cortisol: (1) Cardiovascular: drop in blood pressure. (2) Digestive: anorexia, vomiting, dyspepsia, unexplained hypoglycemia. (3) Neuropsychiatric: dysphoria, drowsiness, memory loss, even coma. (4) Skin and mucous membranes: skin and mucous membrane hyperpigmentation is characteristic, manifesting itself in the exposed parts of the limbs, tongue and gums with hyperpigmented spots of varying sizes. (5) Immunity: Reduced tolerance to trauma, infection, hunger (e.g., fasting hypoglycemia), and other stresses. (6) Reproduction: menstrual disorders, amenorrhea, loss of pubic and axillary hair in women, impotence in men. Adrenocortical crisis is a dangerous condition, once the symptoms appear, we should consult a doctor in time and standardize the treatment.