Whether coronary artery disease can be vaccinated with the new crown vaccine needs to be decided according to the severity of the disease. If the patient’s condition is stable, the new crown vaccine can usually be administered; if the patient’s condition is still unstable, the vaccine is not usually recommended. Coronary heart disease is a common chronic disease, if the disease is effectively controlled, the condition is in a stable stage, usually can follow the doctor’s advice for the new crown vaccine; if the coronary heart disease develops more serious, prone to angina pectoris, this situation is usually not recommended to vaccinate the new crown vaccine, in order to avoid adverse effects. If the patient is allergic to any of the active or inactive components of the vaccine, or if the patient is suffering from an acute exacerbation of a chronic disease, vaccination with the new crown vaccine is contraindicated. Common adverse reactions after receiving the New Crown Vaccine include headache, malaise, fever, localized redness and swelling at the vaccination site, and other adverse reactions, but they usually subside on their own. Coronary heart disease patients need to consult a professional doctor before receiving the new crown vaccine, under the guidance of the doctor for vaccination to avoid adverse effects.