A painful wound sprayed with iodophor may be caused by several reasons. Firstly, the wound itself may have a more serious inflammation or infection, which will cause more intense pain with the slightest irritation. Second, the concentration of iodophor may be too high or the application of tincture of iodine, then the irritation will be stronger, which will easily induce pain. In addition, the patient may have a certain allergy to iodophor, and then not only the wound will be painful, but also the skin in the sprayed area will be red and even have a rash. In addition, the patient himself has a low tolerance for pain, and the slightest irritation will cause severe pain. Generally speaking, iodophor is a disinfectant solution with minimal irritation, and pain is very mild or even non-existent when disinfecting.