Patients with SLE are mainly women, and women of childbearing age are not only a high-risk group, but also a high-risk group for the development of severe lupus. The prevalence of SLE is about 7-9:1 in women:men, and is particularly high in women of childbearing age between 20 and 40 years old, while it is relatively rare in women before menarche and after menopause. The prevalence of SLE in China is about 30.13 to 40.14 per 100,000 people, and among women it is as high as 113 per 100,000 people. Several studies have confirmed the close relationship between estrogen and the development of SLE. Early menarche, oral contraceptives, early menopause and other estrogen-related factors are definitely associated with the development of the disease, and the disease is often aggravated during pregnancy, especially when lupus nephritis is active. In animal studies and clinical trials, it has also been found that blocking the effects of estrogen can improve or reduce the activity of SLE. In addition, because SLE is a genetically related disease with a genetic predisposition, people with a family history of lupus have an increased likelihood of developing SLE compared to those without a family history of lupus. Therefore, women of childbearing age and people with a family history of lupus are at risk for SLE. These people should pay attention to the changes in their symptoms and signs, and if there are signs and symptoms that are suspected of lupus, they should seek medical consultation to investigate the possibility of lupus.