Vulvovaginal ulcers that persist for a long time need to be identified after the cause of the disease and choose standardized medication, surgical treatment, etc., as well as pay attention to daily care. Vulvar ulcers are ulcers and erosions on the vulva due to certain reasons, usually with obvious itching, pain and burning sensation. Vulvar ulcers for a long time patients, need to go to the hospital to find out the cause of the disease, if the combination of other infections can be standardized under the guidance of the doctor to use drugs. If combined with syphilis infection, you can use antibiotic drugs such as benzylpenicillin; if genital herpes, you can use antiviral drugs such as acyclovir; if combined with fungal infections, you can use antifungal drugs such as fluconazole. If the tumor lesions lead to ulceration, the need for surgical resection, malignant tumors require post-surgery adjuvant radiotherapy, commonly used drugs such as cisplatin, paclitaxel. Usually daily care need to pay attention to the cleanliness and hygiene around the vulva, change the underwear, avoid local friction, diet also need to be light, drink more water. Vulvovaginal ulceration for a long time patients, it is recommended that timely consultation to identify the cause of the disease, under the guidance of the doctor standardized treatment.