Taking antihypertensive drugs ankle edema related to drug side effects, may also be hypertension caused by ankle edema. Currently in the clinic antihypertensive drugs are divided into five categories, in which calcium ion antagonists may lead to the emergence of ankle edema, probably because this drug will dilate the capillaries, resulting in increased permeability of the capillaries, which will then induce the emergence of ankle edema, such as nifedipine extended-release tablets. In addition, it may also be hypertension-induced diastolic dysfunction of the heart, increased cardiac afterload, causing vascular reflux obstruction and the appearance of ankle edema. When ankle edema occurs, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.